Anti-emetic drug maropitant induces intestinal motility disorder but not anti-inflammatory action in mice
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چکیده
منابع مشابه
Anti-emetic drug maropitant induces intestinal motility disorder but not anti-inflammatory action in mice
Maropitant is a neurokinin 1 receptor (NK1R) antagonist that is clinically used as a new anti-emetic drug for dogs. Substance P (SP) and its receptor NK1R are considered to modulate gastrointestinal peristalsis. In addition, SP works as an inflammatory mediator in gastrointestinal diseases. Aim of this study is to clarify the effects of maropitant on intestinal motility and inflammation in mice...
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The neurokinin 1 receptor (NK1R) plays an important role in the pathogenesis of acute pancreatitis (AP). Maropitant is an NK1R antagonist that is widely used as an antiemetic in dogs and cats. In the present study, we investigated the anti-inflammatory action of maropitant in a mouse model of AP. AP was induced in BALB/c mice by intraperitoneal administration of cerulein, and maropitant was adm...
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ژورنال
عنوان ژورنال: Journal of Veterinary Medical Science
سال: 2015
ISSN: 0916-7250,1347-7439
DOI: 10.1292/jvms.15-0182